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Abstract
The aim of this study is to determine the safety and efficacy of vaginal misoprostol in termination of second trimester pregnancy in women with previous uterine incisions. The study included 50 patients in their 13-26th weeks gestation according to dates or first trimestric ultrasonography, with previous uterine incisions in whom termination of pregnancy was indicated either due to intrauterine fetal death or fatal structural anomalies. Each of the 50 patients was given 200 æg misoprostol (Cytotec, Searle) vaginally every 4 hours with a maximum of 4 doses /day for 72 hours. Failure of termination was considered if abortion had not been established within 72 hours of the first dose of misoprostol. In such case, the patient became a candidate for termination either by hysterotomy or continuation of the process of induction using higher doses of misoprostol which was left for the attending consultant to decide.