الفهرس 
Quality Assessment and Impurity Profiling of Some selected Compounds in their Finished Products and in Plasma
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Abstract
This thesis dealt with the quality assessment and impurity profiling of some selected compounds in their finished products and in biological fluids. The selected drugs were tropicamide, cyclizine, deferasirox, and deferiprone.
Our aim of this work was to develop simple, sensitive, eco-friendly, and validated analytical methods for the detection and quantitation of traces of the abused drug; tropicamide in rat plasma and then to study its pharmacokinetic parameters. Additionally, the work also designed to quantify cyclizine and its toxic impurities either in its dosage form or in the human plasma by spectroscopic and chromatographic techniques. Also, the work intended to develop a green HPLC method for studying the pharmacokinetics of deferasirox and the concurrently used; deferiprone in rat plasma. The developed methods were compared to the previously reported ones. They were validated according to either ICH or FDA guidelines. The greenness profile was assessed by using various evaluation tools.
This thesis consists of five parts in addition to list of references and two abstracts; English and Arabic abstracts.
Part I: General introduction and literature review.
Part II: Quantitation of the abused intravenously self-administered madness drops (Tropicamide) in rat plasma.
Part III: Quantitation of cyclizine in the presence of its toxic impurities in its pareneral formulation or in human plasma.
Part IV: Quality by design approach for green HPLC method development for simultaneous analysis of two thalassemia drugs in biological fluid with pharmacokinetic study.
Part V: General conclusion.