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Abstract
Purpose: to evaluate efficacy of the glycolic acid gel phonophoresis in treatment of acne vulgaris. Methods of evaluation (Measurement of the Comprehensive acne severity scale (CASS). 30 male and female patients with acne vulgaris, were divided into two groups. group (A) that received the glycolic acid gel phonophoresis program in addition to the routine medical care intervention. group (B) that received the glycolic acid gel plus their routine medical care only, duration of treatment was 5 minutes, every other day for the six weeks as a total period of treatment. Results: showed that both the glycolic acid gel phonophoresis and the glycolic acid gel topical application were effective and had a valuable effects in improving signs and symptoms of acne vulgaris as evidenced by the highly significant decrease in CASS. Conclusion: Glycolic acid gel phonophoresis was more fruitful than the glycolic acid gel topical application that could be attributed to the enhancement effect of phonophoresis in the transdermal drug delivery as evidenced by the highly significant decrease in CASS