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Abstract
The present investigation deals with the design, synthesis, in vitro antiproliferative activity, against MCF- 7 and HEPG -2 cancer cell lines, and VEGFR2 inhibitory activity of certain newly synthesized 1- substituted 2- furylbenzimidazoles and 1- substituted 5- methyl 2- furylbenzimidazoles. Molecular docking of the synthesized compounds on the binding site of VEGFR2 and QSAR studies were also described. In this part a brief survey on the antitumor activity of 2-substituted benzimidazoles and different methods for the synthesis of benzimidazole nucleus were described. This part presents the pharmacological bases and the synthetic strategies upon which the newly synthesized compounds were designed. This part deals with the discussion of the experimental steps performed for the synthesis of the new derivatives. Structure elucidation of the synthesized compounds and mechanisms of the reactions were also discussed. This section explains the conditions and procedures followed to synthesize the following known and new compounds. Description of the spectral physical and microanalytical data were also given