الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Pharmacology and toxicology department, Faculty of pharmacy, Cairo university. The present study aimed to investigate the possible protective effect of pioglitazone on DOX-induced cardiotoxicity. Pretreatment with pioglitazone significantly protected against DOX - induced myocardial damage manifested by decrease in serum CK - MB and LDH. Amelioration of oxidative stress as manifested by decreased heart TBARS content parallel to increased GSH content and catalase activity was also observed. Additionally, it attenuated the inflammation evidenced by decrease in heart TNF- Ü, p38 MAPK and VCAM- 1 content as well as MPO activity. Improvement of histopathological and ECG insults also noticed