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Abstract
The objective of the study is to compare the induction of labour in post date pregnant (280 days) women using vaginal misoprostol versus vaginal dinoglandine as regard the course, the duration, the progress of labour, the occurrence of complications. Also we compare the effect of both drugs on the fetus regarding the umbilical cord ph and the apgar score. This study had included 60 women {u2265} 40 weeks of pregnancy without medical complications. They were divided into 2 groups: first 30 patients received vaginal misoprostol and last 30 patients received vaginal dinoglandin. They had been chosen from the pregnant women attending the casualty department of gynecology and obstetrics at Cairo university Hospital. There were no statistically significant differences in the doses of medication given to the patients or in their Bishop scores at the time of admission but after 6hrs bishop score was changed to: (mean + 4.77) for mesoprostol and (mean = 4.17) for dinoprostone and after 9hrs it was (mean = 6.60) for mesoprostol and (mean = 5.59) for dinoprostone which reflect the efficacy of mesoprostol more than dinoprostol. Cesarean delivery occurred more frequently in patients who received dinoprostone than in patients who received misoprostol (43.3%and 26.7%, respectively) and normal delivery occurred more frequently with misoprostol (73.3%) than dinoprostone (56.7%) but this difference was not statistically significant. There were no significant differences between the groups regarding operative vaginal delivery, presence of meconium, blood cord ph, number of newborns with apgar score less than 6 at 5 minutes, or admissions to the neonatal intensive care unit.