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Abstract
The present clinical studies were carried out to investigate selected oxidative stress markers in stress- related skin diseases of dogs. The studies were applied on a total number of 83 dogs of different breeds, their ages ranged from 2 months to 13 years. Dogs were classified into: apparently healthy group, flea allergy dermatitis group (FAD), demodicosis group, dermatophytosis group, pyoderma affected group, tick infested group and allergy contact dermatitis (ACD) affected group. Clinical, hematological, biochemical constituents and oxidative stress biomarkers were analyzed. Clinical presentations of examined groups revealed significant heamato-biochemical alterations include increase in red blood cells count (RBCs) in allergy contact dermatitis affected group, decrease in hemogram activity in demodecosis infected dogs, leucocytosis in FAD, demodecosis, pyoderma and ACD, neutrophilia in demodecosis, pyoderma and ACD infected group, neutropenia in tick infestation, eosinopenia in demodicosis and pyoderma groups but eosinophilia in FAD and tick infestation group, and monocytopenia in ACD also, lymphocytopenia in demodecosis and ACD dogs. Serum biochemical analysis revealed an increase in alanine aminotransferase (ALT), alkaline phosphatase (ALP), blood urea nitogen (BUN). Oxidative stress markers analysis revealed significant increase in superoxide dismutase (SOD) in demodecosis and ACD groups along with significant decrease in glutathione peroxidase (GPx) in demodecosis, dermatophytosis and pyoderma groups, decrease in Catalase (CAT) level in pyoderma group and plasma zinc levels in FAD, dermatophytosis and ACD groups