الفهرس Only 14 pages are availabe for public view
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Abstract
Muscle strains account for about 31% of all sports injuries. Stretching and platelet rich plasma (PRP) have been suggested as therapeutic interventions. However, their effectiveness is still lacking solid scientific evidence. This study aimed at investigating the effect of PRP and stretching on healing and functional recovery of tibialis anterior induced muscle strain in rats. Forty male Wistar rats were used in this study, five were used for PRP preparation and thirty five were randomly and equally divided into 5 groups. Tibialis anterior strain was induced using a weight equal to 150% of the animal weight. Following strain induction, animals in group I were injected with PRP, whereas those in group II received stretching exercises. group III animals were injected with PRP, in addition to passive stretching. Animals in group IV and V served as sham and positive control, respectively. The primary outcome measure was based on a histopathology scoring that was developed to measure inflammatory cells, edema, hemorrhage, collagen organization, damaged myocytes, regenerating myocytes, vascularity, and matrix accumulation. The secondary outcome measure was the functional recovery, determined by the sciatic functional index (SFI). PRP and stretching applied individually or combined have beneficial effects at tissue level compared to control. Functionally, SFI showed no difference between treatment and control groupsPRP and stretching applied early following muscle strain improves tissue healing with no apparent effect on reversing functional impairment associated with the strain injury