الفهرس Only 14 pages are availabe for public view
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Abstract
Background: Identification of prognostic factors in ALL patients is most important for stratifying patients into risk groups and 2tailoring3 treatment accordingly. Molecular and cytogenetic abnormalities are the most important prognostic factors. Minimal residual disease (MRD) is also an important predictor of relapse in ALL. However, correlation of both prognostic variables has not been thoroughly studied. Material and methods:In this study we investigated the correlation between defined cytogenetic abnormalities and selected new MRD markers (CD79b, CD123 and CD200) in 40 newly diagnosed Egyptian pediatric B-ALL patients. Results: CD123 found to be expressed in 45% of patients and CD200 was expressed in 82.5% of them, while CD79b was negative in 32.5% of patients. MRD analysis during treatment showed stable expression patterns of CD200. There was significant association of CD123 expression with hyperdiploid-ALL group (P=0.039). Another association (P=0.031) was found between CD79b negativity and t(12;21) group. CD200 was widely expressed in all groupsc subgroups (CD123 and hyperdiploidy