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Abstract
The role of inflammation has received increasing attention as a potential pathophysiological mechanism in bipolar disorder. To compare the level of soluble tumor necrosis factor receptor 1 in different phases of bipolar disorder and in healthy controls. Then, to investigate if there is a relation between the level of soluble tumor necrosis factor receptor 1 and the severity of bipolar illness. Serum levels of soluble tumor necrosis factor receptor 1 were measured with enzyme linked immunosorbent assay techniques in 88 patients with bipolar disorder (44 patients in manic episode and 44 patients in full remission) and 88 healthy controls. The patients were recruited from psychiatry and addiction hospital Kasr Alainy both from the inpatient wards and from the outpatient clinic. Healthy controls were recruited from workers in other departments. Patients were subjected to the young mania rating scale to assess the severity of the manic symptoms. Patients with bipolar I disorder, in full remission were further subjected to hamilton depression rating scale. The level of soluble tumor necrosis factor receptor 1 was highest in patients with Bipolar I disorder, most recent episode manic. Patients with bipolar I disorder, most recent episode manic with psychotic features had higher levels of soluble tumor necrosis factor receptor 1 than those without psychotic features. Higher level of soluble tumor necrosis factor receptor 1 may be considered as state marker in manic episodes in patients with bipolar disorder. The more severe the disease, the more the level of soluble tumor necrosis factor receptor 1