الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
In recent years, many classes of pharmaceutical compounds have been detected in aquatic environment such as natural waters, wastewaters, drinking water, sludge and sediment. Such occurrence has provoked a concern regarding their potential effects on environment and human health. Pharmaceutical wastewater is regarded as one of the major sources of pharmaceutical compounds to enter the environment through continuous discharge of pharmaceutical wastewater into wastewater treatment plants. Conventional treatment plants are not equipped to deal with complex pharmaceuticals. Inadequate removal of such compounds has resulted in their presence in water samples worldwide. In this work, advanced oxidation processes have been employed in the photodegradation of three selected drugs; meloxicam, 6- mercaptopurine and methotrexate. The photocatalytic degradation of meloxicam using commercially available titanium dioxide nanoparticles and synthesized gallic acid magnetic nanoparticles was investigated. High performance liquid chromatography and capillary zone electrophoresis assays were used to monitor meloxicam concentrations in the presence of its photodegradation products. Factorial design was employed to optimize the performance of the photocatalytic system. Kinetics of degradation was also studied. The optimized protocol was applied on wastewater samples collected during the cleaning validation of the production lines of meloxicam. In addition, the photodegradation of photosensitive antineoplastic drugs; 6- mercaptopurine methotrexate was conducted in the absence and presence of titanium dioxide nanoparticles. Stability indicating high performance Liquid chromatography and spectrophotometric assays were used to monitor each drug concentration in the presence of its photodegradation products