الفهرس Only 14 pages are availabe for public view
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Abstract
To add more insight to the role played by TGFÝ 1 in psoriasis, by studying its gene polymorphism in codon 10 in the blood of psoriatic patients. It also aimed to analyze the relationship between TGF- Ý1gene polymorphism and susceptibility of psoriasis in a sample of Egyptian patients. Patients and methods: This case control study included 70 patients and 100 controls examined for TGF-Ý1 gene polymorphism by PCR-RFLP. Results: Statisticaly significant difference was found between psoriatic patients and control regarding TGF-Ý1 gene polymorphism at codon 10,morover Statistically significant difference was found between cases with normal genotype and those with polymorphic mutant genotype regarding postive family history of psoriasis (P=0.004),No statistically significant difference was found between cases with normal genotype and those with polymorphic mutant genotype as regard the sex (P=0.50), duration of illness (P=0.57), onset of disease either early or late onset (p=0.051), severity according to PASI score (P=٠.٨٢)، associations with psoriatic arthritis(P=0.24) . Conclusions: Egyptian psoriasis sample patients showed increased TGFÝ1 gene polymorphism in the blood compared to controls which prove that the TGFÝ 1 gene polymorphism in codon 10 is associated with susceptibility to psoriasis