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Abstract
Fifty critically ill patients receiving enoxaparin prophylactic dose (40mg/day) were included in the study. Creatinine clearance was measured and patients were divided into two groups: normal kidney function group (group C) and augmented renal clearance group (group A). serum anti-factor Xa was measured at baseline, four hours, 12 hours, and 24 hours. Both groups were compared regarding demographic data, severity scores, kidney function, and anti-factor Xa activity.Results Twenty patients (40%) showed ARC and thirty patients (60%) showed normal kidney function. Creatinine clearance was 214±6 in group A versus 112±11 in group C (P=0.001). Serum anti-factor Xa levels was similar in the two groups after four hours (0.2±0.07 Vs 0.2±0.05, P=1). Serum anti-Xa levels were significantly lower in group A compared to group C at 12 and 24 hours (0.06±0.03 Vs 0.1±0.04, P=0.004), (0.01±0.01 Vs 0.05±0.01, P=0.001) respectively.Conclusion ARC patients showed short activity of enoxaparin. This finding draws the attention towards dose adjustment in this type of patients