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Abstract
The Present work has been carried out to investigate: A- Development and validation of a rapid RP-HPLC method for determination of paracetamol with fexofenadine hydrochloride in pure drugs and in binary pharmaceutical dosage forms. B- RP-HPLC stability-indicating method for estimation of irbesartan and hydrochlorothiazide in bulk and pharmaceutical dosage form. C- Validated stability-indicating RP-HPLC-method for the determination of Sofosbuvir in pure drug and in tablet dosage form. D- Stability-indicating spectrophotometric method for the determination of sofosbuvir in bulk and pharmaceyitical formulation