الفهرس 
Association between Angiotensin I-Converting Enzyme (ACE) gene polymorphism And Vaso-Occlusive Crisis (VOC) In Egyptian sickle cell disease patients
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Abstract
Background and objectives: SCD is one of a group of conditions known as hemoglobinopathies.Hemoglobinopathies are characterized by reduced production of normal hemoglobin protein and/or production of abnormal hemoglobin protein. The frequency of the various genotypes of the ACE I/D polymorphism among SCD patients is not established, with geographic variations. The aim of the study is to detect the possible association between angiotensin I-converting enzyme (ACE) gene polymorphism and vaso-occlusive crisis (VOC) in Egyptian Sickle cell Disease patients. Method: The present study was conducted on 100 patients with Sickle cell disease, Their ages ranged between 1-38 years. One hundred age and sex matched healthy volunteers were included in the current study as a control group. Detection of angiotensin I-converting enzyme (ACE) gene polymorphism by multiplex polymerase chain reaction (Multiplex PCR) was performed.Conclusion:It is not evident in our study that there is an association between angiotensin I-converting enzyme (ACE) gene polymorphism and vaso- occlusive crisis (VOC) in Egyptian Sickle cell Disease patients