الفهرس 
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Abstract
The aim of this study is to evaluate the antitumor activity of three Schiff base
complexes in Nano size particles (copper, zinc and mixed copper/zinc complexes NPs)
in the treatment of hepatocellular carcinoma induced in rats both invitro and invivo, and
the ability of these complexes to ameliorate the antioxidant system, improve the liver
functions, histopathological alternations induced by the tumor, reduce proliferation and
induce apoptosis in hepatocellular carcinoma.
Methodology:
Transmission electron microscope:
TEM samples for the colloidal suspensions of Cu complex, Zn complex and
mixed copper(II)-zinc(II) complex in distilled water were prepared by dropping the
colloids onto carbon-coated TEM grids (Carbon coated Cu grids, Ted Pella, Redding,
CA, USA) and allowing the liquid carrier to evaporate in air then assaying by a JEOL
1230 transmission electron microscope (120 kV).
Animals:
110 healthy male albino rats 8 weeks old (180 - 200 g) were purchased from
National Cancer Institute, Cairo, Egypt. Rats were housed in cages at regulated
temperature (22- 25 °C). They were kept under good ventilation under a photoperiod
of 12-h light/12-h darkness schedule with lights-on from 06:00 to 18:00. They all
received a standard laboratory diet (60% ground corn meal, 10% bran, 15% ground
beans, 10% corn oil, 3% casein, 1% mineral mixture and 1% vitamins mixture),
purchased from Meladco Feed Company (Obour City, Cairo, Egypt) and supplied
with water ad libitum throughout the experimental period.