الفهرس 
Diabetes Mellitus and Coronary Artery DiseasesOnly 14 pages are availabe for public view
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Abstract
Background: In patients with diabetes mellitus (DM), compared with those without DM, (CAD) tends to be more diffuse, complex, and associated with increased morbidity and mortality from cardiovascular disease. The SYNTAX score (SS) uses coronary anatomy to objectively guide decisions regarding mode of revascularization. It characterizes the extent of coronary disease in terms of the number of lesions, their functional importance, and their complexity.
Aim of the study: The aim of this study was to assess the correlation between fructosamine level and the severity of CAD by calculating SYNTAX and GENSINI scores in diabetic patients presenting to Ain Shams University Hospital with symptomatic chronic coronary syndrome undergoing elective coronary angiography.
Patient and Methods: This study was conducted on 200 diabetic patients with chronic coronary syndrome undergoing elective coronary angiography, with mean age 54.36 ± 5.86 years ranging from 32 years to 65 years. The majority of them were males (64%).
Results: A total of 200 diabetic patients were included in the study. Mean age was 54.36±5.86 years. Of the total 64% (128) were males, 74% (149) were hypertensive and 57% (113) were smokers. We found that higher Fructosamine level was strongly correlated with disease severity and higher SYNTAX as well as GENSINI score as fructosamine and SYNTAX score (r=0.668) and with GENSINI (r=0.734) (p-values <0.001 and <0.001 respectively). A significant increase in fructosamine level was noted in higher tertiles of SYNTAX and GENSINI scores (p-values <0.001 and <0.001 respectively). There was also a positive correlation between both HbA1c and SYNTAX score (r=0.636) and with GENSINI score (r=0.716)
Conclusion: As a result of this study it was found that a significant correlation was detected between serum fructosamine level and severity of CAD assessed by the angiographically derived SYNTAX and GENSINI scores and fructosamine may have a value as a predictor of severity of CAD and risk stratification of diabetic patients as patients with a higher level of fructosamine had significant severe lesions with higher SYNTAX (third tertile >32) and Gensini (third tertile >38).In addition to that a strong positive correlation was found between markers of glycemic variability fructosamine and HbA1c.