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Abstract Background Redo mitral valve surgery has a significant mortality and morbidity. The mitral valve may be accessed directly through the left atrium which can sometimes be challenging. A trans-septal interatrial approach provides another method for exposure. This retrospective study evaluates the difference in short term outcomes between the left atrial approach and the trans-septal approachin patients that underwent previous cardiac surgeries. Methods and Results We analyzed patients in Cairo University Hospitals and other hospitals from January 2017 to November 2021. A total of 100 patients, 50 underwent trans-septal approach and 50 underwent left atrial approach. In group 1 trans-septal group cross-clamp time was 78.84 minand in group 2 left atrial group it was 79.3 min. No statistical difference (p=0.284) while cardiopulmonary bypass time was 90.64 min and 91.1 min, respectively (p=0.62). Postoperative blood loss was 312 mL (trans-septal gp 1) vs 318 mL (Left atrial gp 2)) (p=0.244). No significant difference was found in the incidence of postoperative atrial fibrillation (p=0.31) . Heart block in trans-septal group 1 22% and in left atrial group 2 6% which was statistically significant.(0.021). Conclusions The TS approach when compared to left atrial approach in mitral valve surgeries in redo patients provide comparable results in intra-operative and post operative outcomes, there is only a higher in incidence of heart block in trans-septal approach |