الفهرس 
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Abstract
Our study aimed at evaluation the diagnostic and prognostic role of ascitic fluid (AF) calprotectin and its ratio to-total protein in spontaneous bacterial peritonitis
(SBP).
Methods: In our study, 90 cirrhotic Egyptian patients with ascites were collected from the Gastroenterology, Hepatology and Infectious Diseases Department at Kafrelsheikh University Hospital. Diagnostic abdominal paracentesis was performed for all patients as well as measuring ascetic fluid calprotectin. Patients were followed for development of SBP or mortality.
Results: In the current study, 90 cirrhotic patients with ascites were enrolled. SBP patients had significantly higher calprotectin, and calprotectin/total protein ratio, laboratory data revealed significantly calprotectin [median (range): 1240.0 ng/ml in SBP patients versus 364.0 ng/ml in non SBP patients, p<0.001], and calprotectin/total protein ratio [median (range): 756.8 ng/ml in SBP patients versus 348.2 ng/ml in non SBP patients, p<0.001]. Logistic regression analysis identified AF calprotectin as a significant predictor of mortality [OR (95% CI): 1.04 (1.0-1.06), p=0.013]. It was also shown non-survivors had significantly higher AF calprotectin [median (range): 1782.0 ng/ml versus 1160 ng/ml, p=0.049] and calprotectin/total protein ratio [median (range): 972.8 ng/ml versus 723.4 ng/ml, p=0.015] when compared with survivors.
Conclusions: According to our research, ascites calprotectin levels and its ratio to total protein may serve as an accurate diagnostic and predictive biomarker for SBP.
MeSH Keywords: Ascitic Fluid, Ascites, Gastroenterology, Prognosis, Paracentesis, Peritonitis, Liver Cirrhosis, Communicable Diseases, Morbidity.