الفهرس 
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Abstract
PCOS, or polycystic ovarian syndrome, is a hormonal and metabolic condition that affects many women of childbearing age.
In addition to the acne and hirsutism associated with the condition, other symptoms include monthly abnormalities, most usually in the form of oligoamenorrhea. This is a multifactorial heterogenous ailment.
This condition has a slew of different labels attached to it, each with its own unique set of criteria.
Currently, the Rotterdam definition of PCOS is endorsed by the majority of scientific organisations and health authorities.
At least two of the following three features must be present for a woman to be diagnosed with PCOS:
Hyperandrogenism, ovulatory dysfunction, and PCOM are all symptoms of this condition.
Non-classical congenital adrenal hyperplasia and hyperprolactinemia, as well as androgen-secreting malignancies, must also be ruled out.
PCOS is usually linked to obesity, insulin resistance, metabolic diseases, and cardiovascular risk factors in women.
Infertility is a typical problem for women with PCOS, since the condition affects the development and ovulation of the follicles, resulting in the inability to conceive. 100 PCOS-affected infertile women were divided into two groups for the purposes of this research.
The women in group A were given 100mg of clomiphene citrate daily, starting on day 3 of the menstrual cycle and continuing for five days.
As on day 3, group B was given letrozol 5mg every day for up to five days.
Polycystic ovarian women who were trying to conceive were given these medicines as ovulation inducing agents, and the rate of ovulation and the result of either pregnancy or problems were compared between the two groups.
You may tell the exact moment of ovulation by using ultrasonography to monitor the peak development of the prominent follicles (when they reach a mature size of 18mm or more) and the subsequent shrinkage. In artificial reproductive procedures, this period is utilised as the standard reference for ovulation detection since it can be precisely defined in this way.
In both urine and serum, the luteinizing hormone (LH) surge is very sensitive and specific for ovulation, and so gives excellent accuracy in estimating conception capability.
Repeated ultrasounds during follicular maturation may detect an imprisoned mature oocyte, which can be released after the action of LH but remains large and undergoes luteinization for a week thereafter, resulting in the LUF syndrome.
After ovulation inducement, LUF is a major concern, and some believe it is a significant cause of unexplained infertility.
In normal menstrual cycles, this condition may occur, although it is more common in stimulated periods.
In contrast to letrozole-stimulated cycles, clomiphene citrate cycles dramatically enhanced the incidence and recurrence of LUF in PCOS patients.
In terms of the likelihood of an OHSS or a first-trimester abortion, there was no significant difference between the two groups.
However, the incidence and recurrence rates of LUFS differed significantly. clomiphene has been linked to an increased risk of LUF development.
Letrozol may be a suitable option for ovulation induction in women with PCOS since it has a high ovulation rate, monofollicular development, and low risk of OHSS and multiple pregnancies, according to our research.