الفهرس 
Title : Expected protective role of Physalis pubescens L. plant extract against neuronal impairment associated with diabetes in rats
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Abstract
Diabetes mellitus (DM) is a chronic metabolic disorder that may develop in serious complications such as neural impairments. The current study aimed to evaluate the protective effect of Physalis pubescens L. juice (PJ) against the neural damage in streptozotocin (STZ)-induced diabetic rats. Thirty adults male Wistar rats were divided randomly and equally into five main groups; the control, those administered 5 ml PJ daily (PJ), those injected intraperitoneally with 55 mg/kg STZ without treatment (STZ), or treated with PJ (STZ+PJ), or administered 500 mg/kg metformin (STZ+Met) groups, for 28 days. At the end of experiments, six rats form each group were dissected to obtain the brain cortex. In the STZ group, the blood glucose level as well as the brain levels of interleukin- 1β, tumor necrosis factor alfa, nitric oxide, malondialdehyde, B-cell lymphoma- 2 associated X-protein, and mRNA of caspase-3 were significantly higher than the controls. However, the levels of monoamines, glutathione, brain-derived neurotrophic factor, B-cell lymphoma-2, and the mRNA levels of superoxide dismutase, glutathione peroxidase, catalase, and glutathione reductase in the brain of STZ group were remarkably lower than the controls. Moreover, some histopathological modifications were noticed in the brain of the STZ group. Inversely, the PJ administration considerably hindered all the above-mentioned changes in all the studied parameters in the brain cortex. In conclusion, an oral administration of 5 ml PJ/kg revealed a neuroprotective action against DM- induced neural damages in rats.