الفهرس 
Formulation and evaluation of biodegradable implants loaded with a certain statin drug for tissue regeneration
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Abstract
Tissue engineering has emerged as an interesting field nowadays; it focuses on accelerating the auto-healing mechanism of tissues rather than organ transplantation. It involves either implanting an in-vitro cultured tissue with the aid of polymers or an implant loaded with tissue regenerating ingredients at the damaged area. Both techniques are based on the use of biodegradable biocompatible polymers as scaffolding materials which are either derived from natural (e.g. alginates, celluloses, and zein) or synthetic (e.g.polylactide-co-glycolide (PLGA), polycaprolactone (PCL), polylactic acid (PLA))sources. As well, smart biomaterials (e.g. chitosan and sodium alginate) are fascinating candidates in the field as they are capable of elucidating a chemical or physical transformation in response to external stimuli (e.g. temperature, pH, magnetic or electric fields). Generally, tissue regeneration approaches could be applied to repair damages in soft (e.g. muscles, skin, tendons) as well as hard (e.g. bones)tissues.
Pitavastatin is a statin drug used to treat hypercholesterolemia, yet, it has been reported that it possesses tissue regenerative properties via various mechanisms. The work in this thesis focused on the formulation of pitavastain-loaded matrices made from natural biopolymers for the treatment of bone defects as well as full-thickness wounds.
To achieve these goals, the work in this thesis was divided intotwo chapters:
• Chapter I: Dual-Drug Delivery via Zein In-Situ Forming Implants Augmented with Titanium-Doped Bioactive Glass for Bone Regeneration: Preparation, In-Vitro characterization, and In-Vivo Evaluation.
• Chapter II: 3D Nanocomposite Alginate Hydrogel Loaded with Pitavastatin Nanovesicles as a Functional Wound Dressing with Controlled Drug Release; Preparation, In-Vitro and In-Vivo Evaluation.