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Abstract During the outbreak of the profoundly infectious Coronavirus disease 19, quick and straightforward prognostic instruments were contemplated e.g. the ROX index and the lung ultrasound score (LUSS) to help clinical choices and anticipate the need of invasive mechanical ventilation, in addition to clinical assessment. OBJECTIVE: The study aimed to compare lung ultrasound score with ROX index in predicting the need of invasive ventilation in COVID-19 patients requiring advanced oxygen therapy. METHODS: Fifty patients with moderate to severe COVID-19 pneumonia were admitted to the intensive care unit in the isolated area at Kasr Al-Ainy hospital. Medical history and laboratory data were recorded on admission. All patients went through bedside lung ultrasonography scan and LUSS was determined at the second and the twelfth hour, additionally ROX index was determined at the second, sixth and twelfth hour from starting the advanced oxygen therapy. RESULTS: from a total of 50 patients with COVID-19, 56.0% were males, the mean age was 65.98 + 11.68, and mortality rate was 66%. The ideal cut off values of the ROX index at (2, 6, 12 hour) were (2.495, 2.675, 3.06) respectively, (p <0.001) with sensitivity 90.9% and specificity 76.5% at the 12 hour. Likewise the ideal cut off point of LUSS was 25.50 (p <0.001) with sensitivity 93.9% and specificity 88.2% for prediction of the mechanical ventilation. There was no statistically significant difference between the type of advanced oxygen support either high flow nasal cannula or non-invasive positive pressure ventilation and the need of invasive ventilation (p =0.558). CONCLUSION: Our study concluded that LUSS was more sensitive in predicting the need of invasive .mechanical ventilation than ROX index. |