الفهرس | Only 14 pages are availabe for public view |
Abstract Neonatal sepsis is the cause of substantial morbidity and mortality. Precise estimates of neonatal sepsis burden vary by setting. Differing estimates of disease burden have been reported from high-income countries compared with reports from low-income and middle-income countries. The clinical manifestations range from subclinical infection to severe manifestations of focal or systemic disease. The source of the pathogen might be attributed to an in-utero infection, acquisition from maternal flora, or postnatal acquisition from the hospital or community. The timing of exposure, inoculum size, immune status of the infant, and virulence of the causative agent influence the clinical expression of neonatal sepsis. Immunological immaturity of the neonate might result in an impaired response to infectious agents. This is especially evident in premature infants whose prolonged stays in hospital and need for invasive procedures place them at increased risk for hospitalacquired infections. The present study is a prospective case control study conducted on 50 neonates with sepsis (cases) and 50 neonates without sepsis (controls), 42 out of septic neonates survived while 8 did not. The aim of the study is to assess the ventricular function in neonates with sepsis using tissue Doppler imaging (TDI). Results of the statistical analysis in this study showed that there was non-significant difference between all studied groups regarding the demographic data (age, sex, gestational age, mode of delivery and consanguinity). Prematurity was a highly significant risk factor for sepsis between cases and control groups. Also, anthropometric measurements were Summary - 121 - significantly different between all groups. All the clinical signs of sepsis score were also of significantly different between cases and controls. The laboratory investigations showed a significant difference between cases and controls regarding all parameters of complete blood count and hematological sepsis score. Also the results of blood culture among cases reported higher incidence of gram negative infections rather than gram positive ones. Staph aureus was the most common isolated organism. The most common complication of sepsis noted in this study were septic shock, DIC, NEC, and multi-organ failure with high significant difference between survived and non-survived regarding DIC. The echocardiographic data in both cases and controls and survived and non-survived cases were all of no significant difference. Same was reported regarding results of tissue doppler imaging. |