الفهرس | Only 14 pages are availabe for public view |
Abstract There is a lack of clarity regarding the optimal dose, ideal local anesthetic volume, and concentration for mTLIP block. This study was designed to investigate the analgesic efficacy of two different volumes of Bupivacaine 0.25% (20ml, and 10ml) for ultrasound-guided mTLIP block in patients undergoing lumbar spine surgeries. Method: This randomized controlled double-blinded study. Patients received single shot of bilateral mTLIP block at the mid-level of the operative intervention and were randomly allocated into one of the two groups to receive either10 or 20 ml 0.25%bupivacaine on each side. Time to first rescue analgesia was set as the primary outcome. Total morphine consumption in the first 24 hours postoperative and Numeric Pain Rating Scale at rest and during movement were set as secondary outcomes. Results: Time of first request of rescue morphine was significantly lower in 10 ml group (7.80 ± 3.98) compared to 20 ml group (13.23 ± 3.00) (P value <0.001). On the other hand, there was no significant difference in the total dose of postoperative morphine consumption over the first 24 hrs was higher in 10 ml group (6.20 ± 2.18) compared to 20 ml group (5 ± 0.00) (P value =0.056). NRS at rest and movement in all time measurements (30min, 2h, 4hr, 6hr, 8hr, 12hr, 16hr, 20hr and 24hr postoperative) was significantly higher in group (10ml) compared to group (20ml). Conclusion: The mTLIP block using 20 ml of 0.25 % bupivacaine increased the postoperative total analgesic duration for lumbar spine surgeries, decreases total morphine consumption in the first 24 hours postoperative and produces less postoperative numerical rating scale compared to 10 ml of 0.25 % bupivacaine. Clinical trial registration: The study was registered at clinicaltrials.gov (NCT 05276908) |