الفهرس 
Neonatal SepsisOnly 14 pages are availabe for public view
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Abstract
Neonatal sepsis is a syndrome featured by non-specific signs and symptoms of systemic infection accompanied by bacteremia in the first 28 days of extra uterine life. This condition is a public health problem that still contributes to mortality and morbidity in neonatal intensive care units. Therefore, clinicians must start empirical antibiotic therapy based on a combination of maternal and neonatal risk factors, as well as clinical signs and symptoms that do not take into account the particularities between every single patient. Survivin, one of the members of the inhibitor of apoptosis protein, has been demonstrated to be a regulator in the injury of several organs including lung, kidney, and liver. Moreover, studies reveal that the survivin is interacted with inflammatory pathways (such as nuclear factor-kappa B (NFkB)) to play a vital role in lipo-polysaccharide induced cytotoxicity Based on this information, we hypothesized that survivin might be a critical regulator in sepsis, however, relevant research is limited. Therefore, in support of decision-making for clinicians the day of sepsis suspicion, and as an additional non-invasive test, the aim of this work is to estimate the diagnostic and prognostic role of serum Survivin in neonatal sepsis. The studied patients included 60 neonates classified into: group I (Cases): consisted of 30 neonates suspected as neonatal sepsis by Clinical & Hematological sepsis scores and/or confirmed by blood culture & group II (control): consisted of 30 healthy neonates matching cases in gestational age, age & sex. All neonates included in the study were subjected to the following: Full history taking including: Age, Sex and Gestational age, Obstetric history, Prenatal history, Postnatal history and Present history which includes most common symptoms of sepsis, Full clinical examination:
focusing on: General examination: Measurement of blood pressure, temperature, respiratory rate, and heart rate, Local examination: Chest, abdominal, cardiac, neurological examination, gestational age/weeks, Birth weight/kg, detection of clinical signs of sepsis and Clinical and hematological scores of sepsis. Routine investigations: including CBC, Kidney function tests, Hepatic function tests, Serum electrolytes, CRP & Blood culture. Special investigations including serum Survivin level.