الفهرس 
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Abstract
BPA is one of the most utilized industrial chemicals worldwide. It is commonly found in a variety of consumer products, particularly in those of polycarbonate plastics and epoxy resins. BPA has been demonstrated to be associated with oxidative stress and disorders of the mitochondria.
Taurine, (2-amino-ethane-sulfonic acid), is the most abundant intracellular amino acid. It exhibits antioxidant activity . Additionally, taurine has been shown to protect cells against the cytotoxic effects of inflammation associated with oxidative stress and to provide anti-inflammatory effects.
The present study aimed to study sub-acute toxic effect of BPA on liver, blood and colon. Also, studied the possible protective effect of taurine on target organ against toxicity of BPA.
The study was conducted on 40 adult male healthy albino rats weighing 200 ± 20 g. The ethics and husbandry conditions of animal research were considered according to guide of care and use of laboratory animals approved by the scientific Ethics Committee of Faculty of Medicine, Sohag University.
The rats were divided randomly into 4 groups:
group I (negative control group) : The rats were fed on basal diet and distilled water.
group II : The rats were treated orally with taurine at the dose of 100 mg /kg body weight/day for one month
group III: The rats were treated orally with BPA at dose of 130 mg /kg body weight /day for one month.
group IV: The rats were treated with BPA and taurine at the previously mentioned doses for one month.
Biochemical results:
Results of liver functions tests:
• Serum levels of ALT and AST were higher than normal in animal groups that received a toxic dose of BPA without taurine.
• Co-administration of taurine with a toxic dose of BPA may prevent an increase in serum ALT and AST levels.
Results of hematological tests (CBC):
• There was a decrease in all measured RBCs indices (RBCs, Hb, HCT, MCV and MCH) in BPA treated group.
• There is an increase in WBCs and neutrophil count in BPA treated group.
• There is a decrease in lymphocyte count in BPA treated group.
• There is an increase in platelets count in BPA treated group.
• Improvement of blood parameters after treatment with taurine for one month.
Histopathological results of the study groups:
• Liver histopathological results:
Many histopathological changes were seen in the BPA-treated group, including significant dilatation and congestion of central veins and portal venules.
There was also obvious necrosis of the hepatocytes, when BPA was combined with taurine for one month, these hepatic changes improved.
• Colon histopathological results
There was an increase in the infiltration of the lamina propria with inflammatory cells and congested dilated blood vessels in the BPA-treated group. Some mucosal cells appeared to be degenerated, while others had necrotic nuclei. Smooth muscles appeared to be vacuolated.
Taurine co-administration improved the histological examination of the colon. There are no dilated or congested blood vessels and the height of the crypts is similar to that of the control group in the taurine-treated group.
Conclusion
• It has been found that repeated use or consumption of BPA containing substances has functional and pathological effects on the liver, blood and colon.
• Taurine can protect against BPA-induced hepatotoxicity, blood and colonic toxicity.
Recommendations
• Because of the negative effects on various body systems, it is best to limit the use of BPA-containing tools and goods.
• These goods should be replaced with tools and items labelled bisphenol A free,” but these are prohibitively expensive.
• People should be advised to reduce their use of plastics from unknown sources.
• Further studies to evaluate the hazards of BPA on other body organs.
• Additional experimental studies on the efficacy of taurine against the negative effects of BPA should be conducted.
• More studies needed to elicit the protective effect of taurine on the platelets function and aggregation.
• More research should be done on other antioxidants to determine their efficacy against BPA toxicity.