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Abstract Wide range of benign and malignant lesions may affect the spleen, thus complicating the development of a differential diagnosis that includes both benign and malignant focal lesions (1). Solid splenic masses are encountered in routine clinical practice and cause a diagnostic dilemma. Lesions can be discovered incidentally on imaging studies performed for another causes. Malignant solid splenic lesions include lymphoma, leukemic infiltrates, metastases, and angiosarcoma (2,3). The most common benign solid splenic focal lesions are hemangiomas, hamartomas, and granulomas (4,5). When focal splenic lesions are discovered on imaging studies, a splenic biopsy is often considered, particularly in patients with extrasplenic malignancies. Because most splenic lesions that which are found incidentally are benign, it might not be necessary to perform a biopsy to all patients with a focal splenic lesions (1). There is a risk of bleeding after a splenic biopsy due to the rich blood supply of the spleen, and focal splenic lesions may not be accessible to ultrasound-guided biopsy due to poor sonic window. |