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Abstract This article-based thesis comprises five chapters in addition to English and Arabic summaries; The first chapter is a general introduction to cancer and its treatment strategies. The second chapter is a review article titled “Comparative Study of the Synthetic Approaches and Biological Activities of the Bioisosteres of 1,3,4- Oxadiazoles and 1,3,4-Thiadiazoles over the Past Decade”. The third chapter presents an original article entitled “New 5-Aryl-1,3,4- Thiadiazole-Based Anticancer Agents: Design, Synthesis, In Vitro Biological Evaluation and In Vivo Radioactive Tracing Studies”. The fourth chapter includes an original article titled “Elaborating 5-(4- chlorophenyl)-1,3,4-thiadiazole scaffold with a p-tolyl sulfonamide moiety enhances cytotoxic activity: Design, synthesis, in vitro cytotoxicity evaluation, radiolabelling, and in vivo pharmacokinetic study”. The fifth chapter consists of an original article entitled “Newly synthesized series of oxoindole–oxadiazole conjugates as potential anti-SARS-CoV-2 agents: in silico and in vitro studies”. |