الفهرس 
Neonatal SepsisOnly 14 pages are availabe for public view
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Abstract
ABSTRACT
Background: Neonatal sepsis is considered to be a systemic inflammatory response syndrome (SIRS) induced by bacteria, viruses, or fungi (yeast) infections. Neonatal sepsis is a major disease threatening the life of newborns, which is also one of the major challenges facing global public health.
Objective: To assess the ability of serum sTREM-1 in predicting the diagnosis and prognosis of early and late onset neonatal sepsis in full term neonates.
Patients and Methods: This cross sectional study included 60 full term neonate in one group which include 60 neonate with early onset sepsis, the second group include the same 60 neonates at Day 4 of sepsis. This study will be conducted after approval of the Research Ethics Committee Faculty of Medicine Ain Shams University, and informed consent will be obtained from the parents or caregivers of participants of Ain shams university NICU department during period from 1/6/2022 to 1/1/2022.
Results: In our study STREM marker decreased at Day 4 after antibiotics therapy and this is matched with GIBOT study. Gibot study suggests that Post-therapy sTREM- 1 levels were significantly decreased 48h after antibiotic intake in septic neonates compared to baseline levels. Thus, decreased sTREM- 1 denotes favorable response and indicates that infection has been controlled. This implies a role of sTREM- 1 in monitoring response to therapy before getting culture results In our study STREM marker was high in negative and positive blood cultures but higher in negative cultures. Our study shows that there was no statistically significant difference found in the level of TLC, hemoglobin and CRP from day 1 to day 4 respectively and also statistically significant decrease in the level of ALT in sepsis group than non sepsis group.
Conclusion: STREM marker was high in proved sepsis patients by blood culture positive and suspected sepsis patients even blood culture negative than improved in the proven sepsis and suspected sepsis patients. Initial level of STREM marker was higher than based level > 5 ng/mL. Used for follow up at day 4 of infection. It was decreased at day 4 infection