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العنوان
Myostatin as a Marker of Reduced Muscle Mass in Children and Adolescents with chronic Liver Disease/
المؤلف
Abass,Heba Abd Elkader
هيئة الاعداد
باحث / هبة عبدالقادرعباس شحاتة
مشرف / أمل عبدالمجيد الفرماوي
مشرف / هبه عصام الخولي
مشرف / فاطمة عبداللاه عبدالله محمود
تاريخ النشر
2023
عدد الصفحات
133.p:
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
طب الأطفال ، الفترة المحيطة بالولادة وصحة الطفل
تاريخ الإجازة
1/1/2023
مكان الإجازة
جامعة عين شمس - كلية الطب - Pediatrics
الفهرس
Only 14 pages are availabe for public view

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from 133

Abstract

Results: The prevalence of malnutrition in the CLD patients was significantly higher than the controls with p value<0.001 and it was as follow: 50% had abnormal weight, 42.85%were stunted and 42.85% had abnormal BMI. Although the prevalence of malnutrition in the cases detected by MUAC (in age group 2-5years) was 33.33%, yet this was not statistically significant compared to healthy control with p value 0.329. As regards the lean muscle mass measured by body composition scale, we found that the prevalence of decreased lean muscle mass was 57.58% in the cases which was significantly higher than the controls with p value<0.001. Our study showed that CLD patients had significantly higher serum myostatin level with median of 757ng/mL and range of (450-825ng/mL) in comparison to median of 120ng/mL and range of (100-140ng/mL) in healthy controls. There was a negative but non-significant correlation between the serum myostatin and decreased lean muscle mass in the cases with p value 0.253 and r -0.205.
Conclusion: Malnutrition is prevalent in children with CLD and decreased lean muscle mass is significantly evident. Serum myostatin level is significantly higher in patients with CLD compared to healthy controls.