الفهرس 
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Abstract
ABSTRACT The present work aimed to investigate the possible pharmacological effects of Chlorella Vulgaris (CV) and Spirulina Platensis (SP) with special reference to their hepatoprotective effect as well as their antioxidant activities were evaluated. Seventy-two Wister albino rats, weighing from 100 to 120 gm were used in the present study. Animals were randomly allocated into 12 groups, each of 6 animals. Groups are divided into two main groups, prophylactic groups, and treatment groups. prophylactic groups include Groups ⅰ, A, B, C, D, E. group ⅰ was maintained as (the control healthy) to prophylactic groups. they received distilled water orally& (1 ml normal saline i.p). group A was used as a control positive (intoxicated with thioacetamide in a dose of 300 mg/ kg b.wt. in the last two days of the month). group B was used as a (standard group) and received silymarin orally in a dose of 100 mg/kg b.wt. for one month and thioacetamide in a dose of 300 mg/ kg b.wt in the last two days of the month. group C was given Chlorella vulgaris orally at a dose of 400 mg/kg b.wt. per day, for one month and thioacetamide in a dose of 300 mg/ kg b.wt in the last two days of the month. group D was given Spirulina Platensis in a dose of 400 mg /kg b.wt and thioacetamide in a dose of 300 mg/ kg b.wt in the last two days of the month. group E was given CV &SP in doses of 400+400 mg /kg b.wt and thioacetamide in a dose of 300 mg/ kg b.wt in the last two days of the month. “Treatment” groups include ⅱ, F, G, H, I, and J. group ⅱ was maintained as (the control healthy) to prophylactic groups. they received distilled water orally& (1 ml normal saline i.p). group F was used as a control positive (intoxicated with thioacetamide. It received thioacetamide (TAA) I.P at the beginning of the experiment in a dose of 300 mg/kg b.wt. for two days, for induction of hepatic injury. group G was used as a (standard group) and received silymarin orally in a dose of 100 mg/kg b.wt. for one month and thioacetamide in a dose of 300 mg/ kg b.wt in the first two days of the month. group H was given CV orally at a dose of 400 mg/kg b.wt. per day, for one month and thioacetamide in a dose of 300 mg/ kg b.wt in the first two days of the month. group I was given SP in a dose of 400 mg /kg b.wt and thioacetamide in a dose of 300 mg/ kg b.wt in the first two days of the month. group J was given CV &SP in doses 400+400 mg /kg b.wt and thioacetamide in a dose of 300 mg/ kg b.wt in the first two days of the month.
Rats treated with thioacetamide significantly decreased serum proteins and Total antioxidant capacity concentrations, PCV, HB, PTS, and WBCS. While it increased urea, creatinine, uric acid, AST, ALT, ALP, and malondialdehyde concentration. Treatment of rats with CV&SP changed serum enzymes and antioxidant levels to close to normal levels against (TAA)treated rats. The action of the extract at a dose of 400 mg/kg b.wt. was different from the standard drug, silymarin at a dose of 100 mg/kg b.wt. we can decide that chlorella Vulgaris and spirulina platensis extract have remarkable hepatorenal protective and antioxidant activity against TAA-induced toxicity. Key Words: Antioxidant, Liver, kidney, microalgae.