الفهرس | Only 14 pages are availabe for public view |
Abstract Our work evaluated the prevalence of MAFLD among health care workers in Beni-Suef university hospitals through screening protocol. We also evaluated the common comorbidities, possible risk factors and possible complications such as liver fibrosis, insulin resistance and silent cardiac affection. After exclusion of subjects who did not fulfill the inclusion criteria, 482 subjects were screened for MAFLD using fibroscan, and it turned out that MAFLD prevalence was 49.2% of the studied group. So, we further divided the included study group into MAFLD and non-MAFLD groups. Through our history taking, examination and investigations, it turned out that MAFLD group had significant higher age, more smokers, less physical activity, higher BMI and WC and higher blood pressure than non-MAFLD group. MAFLD group had significant higher comorbidities; such as DM, HTN, cardiac disease and higher prevalence of metabolic syndrome more than non-MAFLD group. MAFLD group had significant higher rates of dyslipidemia, higher blood sugar profile & IR, higher hypertranaminasemia , higher renal affection and lower serum albumin than non-MAFLD group. MAFLD group had a significant higher rates of liver stiffness/fibrosis than non-MAFLD group assessed by fibroscan, elastography and different fibrosis scores (FIB-4, NFS & APRI) than non-MAFLD group. MAFLD group had higher expected CVD risk assessed by hsCRP and ASCVD score. MAFLD group had higher CV affection when assessed by speckle tracing echocardiography. They had significant lower EF, higher LV filling dysfunction and higher LA diameter than non-MAFLD group. We also found that older age, low physical activity, low hemoglobin content, low serum albumin and higher serum creatinine are all predictors of MAFLD in our adjusted regression models. Our study had some limitations as relatively small study sample and lack of tissue diagnosis for NASH or accurate degree of liver fibrosis/ cirrhosis due to patient refusal. |