الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 135 |  |  |
| | | from | 135 | | |
Abstract
Thyroid dysfunction and diabetes mellitus are closely linked. Several studies have documented the increased prevalence of thyroid disorders in patients with diabetes mellitus and vice versa.
Thyroid disease is common in the general population, and the prevalence increases with age. The assessment of thyroid function by modern assays is both reliable and inexpensive. Screening for thyroid dysfunction is indicated in certain high-risk groups, such as neonates and the elderly
Diabetes mellitus (DM) is a very common disease with a global prevalence rate of 8.5% in adult subjects, most of which are type 2 DM (T2D). T2D is due to insulin resistance associated with insulin deficiency, which may result in carbohydrate derangement and hyperglycemia. Long-term hyperglycemia may cause various acute and chronic complications and is the leading cause of blindness, cardiovascular disease, renal failure, and even death. It is not only a big challenge in the clinical setting but also a heavy burden for public health. Diabetes mellitus and thyroid disease are two areas of broad interest in the field of endocrinology and metabolism. Variation of thyroid hormone concentration, even within the normal range, may portend the onset of type 2 diabetes mellitus (T2DM), especially among those with prediabetes. However, current evidence is mixed. In the current study, we aimed to measure plasma levels of TGAB and TSHRAB to correlate their levels with the plasma levels of HBA1C, HOMA.
This study included 120 patients proved to have thyroid dysfunction by thyroid function tests from Menofia University hospitals. Included
Summary
94
patients were subjected to full history recording, routine laboratory assessment, clinical examination of the neck for any growths or enlargement of the thyroid, and measurement of serum TSH, free t3, free t4, TGAB, and TSHRAB, using Elisa kits
We found a significant relation between thyroid dysfunction and diabetes mellitus which is that Hyperthyroid patients have 3.36 times the risk of being diabetic compared to normal. Hypothyroid patients have 3.12 times the risk of being diabetic compared to normal. The occurrence of T2D in the thyroid disease group was higher than in the control group with a hazard ratio (HR) of 1.23 [95% confidence interval (CI)=1.16–1.31]. Both hyperthyroidism and hypothyroidism were significantly higher than in the control. Significantly higher HR was also seen in female patients, the age category of 18 to 39-year-old (y/o) and 40 to 64 y/o subgroups. A higher occurrence of T2D was also seen in thyroid disease patients without comorbidity than in the control group with HR of 1.47 (95% CI = 1.34–1.60). The highest HR was found in the half-year follow-up. There was a relatively high risk of T2D development in patients with thyroid dysfunctions, especially in the period of 0.5 to 1 year after the presentation of thyroid dysfunctions. The results suggest performing blood sugar tests in patients with thyroid diseases for early detection and treatment of T2D.