الفهرس | Only 14 pages are availabe for public view |
Abstract Introduction: Colorectal cancer is the third most commonly diagnosed cancer worldwide constituting 10 % of total cancer cases, it’s the second cause of cancer deaths worldwide. In Egypt colorectal cancer is the ninth most commonly diagnosed cancer. Surgical resection is the only curative treatment for locoregional colon cancer. Adjuvant chemotherapy was found to be beneficial in stage III disease, while in stage II disease its benefit is less certain. Aim of the Work: Describe the demographics and clinico-pathological features of patients with stage II colon cancer, whether they received adjuvant chemotherapy or not and the outcome of this population as a part of the NCI experience in the period between January 2013 and December 2018. Patients and Methods: This retrospective cohort study was conducted at the National Cancer Institute, Cairo University, and included patients diagnosed with stage II colon cancer in the period from January 2013 to December 2018. Results: A total of 89 patients with stage II colon cancer were included with mean age 50.42 ±13.13 years, 52.8 % were below the age of 50, male patients represented 58.4%, right sided tumors were present in 57.1% of patients and 42.9 % were in left colon, adjuvant chemotherapy was given to 62.8% of patients, Adjuvant chemotherapy was associated with significant improvement in DFS at 5 years 79.6% vs 62.6% (p 0.036) and OS 92.6% vs 76.4% (p 0.026) compared to surveillance only. Conclusion: in our study adjuvant chemotherapy was associated with better DFS and OS in patients with stage II colon cancer compared to surveillance only. |