الفهرس | Only 14 pages are availabe for public view |
Abstract Natural sources, whether they are plants, marine organisms or microorganisms, remain an essential source of exploration for natural chemical entities that can be used in drug discovery to treat many health problems. Among the most important current health problems are cancer diseases, inflammation, microbial infections and health problems related to oxidation. from this point of view, the essential oils of some species belonging to Lamiaceae family were used in this study. Major components analysis of six Lavandula species showed significant variation between species in the quality and quantity of EO composition. All studied lavandula species/varieties appeared to be richest in oxygenated monoterpenes. Lavandula angustifolia, Lavandula hybrida, Hyssopus officinalis and Perilla frutescens were subjected for GC-MS analyses and several biological activities. Analyses by GC/MS of the main constituents showed camphor as the main component in L. angustifolia followed by eucalyptol and endo-borneol, β-cymene, α-pinene and βpinene. L. hybrida essential oil contained eucalyptol as the major component followed by camphor, α-pinene and β-pinene. The major components of H. officinalis essential oil were isopinocamphone that reached, followed by pinochamphone, β-pinene, β-phellandrene, α-thujene and Bicyclo-germacrene. The main constituents of the essential oil of P. frutescens constituent were identified as L-perillaldehyde followed by trans-caryophyllene and D-limonene. In vitro study, anti-inflammatory, anticancer, antioxidant and antimicrobial activities were performed for the essential oil of these species. Each of the four oils showed multiple biological activities, L. angustifolia, L. hybrida, H. officinalis and P. frutescens showed antifungal activity against species of candida and L. angustifolia, L. hybrida, H. officinalis and P. frutescens exhibited moderate anti-microbial activities. L. angustifolia, L. hybrida, H. officinalis and P. frutescens showed good anti-inflammatory activities. L. hybrida, H. officinalis and P. frutescens showed cytotoxicity against various studied cancer cells with different concentrations. It is possible to view the essential oil of P. frutescens as inspiring natural entities to be used in the investigation of natural medicines based on the results that were presented and discussed in this study. Before using them to develop new, effective drug entities, especially as anti-inflammatory and anti-tumor agents, it is crucial to subject them to additional biological studies on experimental animals |