الفهرس 
PRETERM PRELABOUR RUPTURE OF MEMBRANESOnly 14 pages are availabe for public view
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Abstract
Rupture that happens prior to the initiation of contractions in 10% of pregnancy is referred to as ”Prelabour membrane rupture” (PROM). About 3% of women undergo Prelabour Rupture of membrane before 37 weeks of birth, which is considered preterm pre labour membrane breakup (PPROM).
This condition is responsible for one-third of preterm births and raises perinatal morbidity and mortality primarily due to the risk of intrauterine infection, which may lead to early neonatal infection, necrotizing enterocolitis and uterine fetal death.
The fetal membranes are made of two histological layers, the amnion in contact with the amniotic fluid, and the chorion in contact with the maternal decidua. They engrave the fetus during pregnancy and serve as a barrier between the maternal and fetal compartments, supplying both physicochemical and biochemical defense towards external shocks and rising vaginal flora bacteria.
Membrane rupture is a biochemical phenomenon that happens towards the conclusion of birth. The programmed weakening of the Para cervical region, marked by collagen remodeling and apoptosis coupled with uterine contractions that produce stretching and shearing forces, contributes to the breakup of the membranes.
Patients with Preterm Prelabour Rupture of membrane need clinical treatment in a hospital that has the required services for premature babies. When the point of fetal viability is met, Preterm Prelabour Rupture of membrane is initially hospital-based and consists of antibiotic prophylaxis and corticosteroids for fetal lung maturation.
According to current guidelines, inpatient management until birth is considered standard in pregnant women with preterm premature rupture of membranes (PPROM). With the increasing burden on obstetric departments and the growing importance of satisfaction and right to self-determination in pregnant women, outpatient management in PPROM is a possible alternative to inpatient monitoring. The most important criterion for this approach is to ensure the safety of both them other and the child.
Home-care inclusion requirements is based on gestational age, lack of chorioamnionitis, physiological reliability at least 72 hours after Preterm Prelabour Rupture of membrane (up to 7 days depending on the study), cervical dilation, and patient at home. The time between membrane breakup and labor initiation, referred to as latency, is stated to be correlated with neonatal morbidity and mortality.