الفهرس 
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Abstract
This case control study was done on 80 child, 40 of them diagnosed
with autistic spectrum disorders by DSM-V-TR criteria with no another
medical disease and another 40 apparently healthy matched age children, from
their brothers as a control group. All children attended to psychiatric and
neurology clinic, pediatric department, Menoufia University Hospital in
Shebin El Kom city, Menoufia governorate, Egypt during the period study
from April 2019 to January 2020.
All study patients were divided in two groups:
Cases group: included 40 children (31 boys and 9 girls), with ages
ranging from 2 to 11 years with mean of 6.5±2.5 years and diagnosed
with ASDs on the basis of the DSM- V-TR criteria.
Control group: enrolled 40 apparently healthy children (15 boys and 25
girls), with ages ranging from 2 to 11 years, from their brothers. All
controls were also clinically examined by the pediatricians to exclude the
possibility to have any subclinical autistic features.
All cases were subjected to the following:
Detailed history taking with special emphasis on; onset, course and
duration of the disease and age, sex of the patient consanguinity.
Antenatal or maternal history: age at patient’s birth, history of chronic
illness as hypertension, Diabetes mellitus (DM) obesity, depression, epilepsy
and PCO.
During pregnancy: Medications (e.g.: antiepileptic drugs) fever,
bleeding, smoking.
Natal and postnatal history including, complication during labour or
delivery, history of prematurity, gestational age at birth, birth weight, perinatal problems and postnatal course especially occurrence of neonatal hypoxia and
jaundice.
Developmental history (both mental and motor): age of sitting up
without support, walking unassisted, first spoken word and history of
vaccination. Past history including major childhood illnesses, any previous
therapies used to treat the child’s condition .Family history for any similar
conditions, any genetic diseases and other psychological or mental disorders
in the family.
History of exposure to heavy metals, Dental fillings, silver/mercury
fillings in pregnancy, near factory, industry, highway residence anti-D inject,
Taking antibiotics during pregnancy.
scaling the socioeconomic level of their families.
previously prepared questionnaire for assessment of risk factors of
autism spectrum disorders.
Assessment of the quality of life: Overall Quality of Life and General
Health physical health domai, Psychological domain, Social
relationships, Spiritual life and Environmental domain.
Results showed that there were highly significant differences between
cases and control groups regarding:
Gender, history of hypertension, and diabetes mellitus during
pregnancy. Irregular folic–iron intake, fever, bleeding, Induced labor and
precipitous labor
Dental fillings, Silver/mercury fillings in pregnancy and taking
antibiotics during pregnancy, >4.5 kg, Neonatal unit and Jaundice.