الفهرس 
Carbon paste electrodes for The electrochemical determination of promethazine hydrochloride in Its pharmaceutical preparations
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Abstract
Carbon paste electrodes were prepared and used in the modified form for potentiometric and as prepared (unmodified) for voltammetric determinations of PmCl. In potentiometry, the linear concentration range of the calibration graph was found to be 1 {u00D7}10⁻⁵ - 6 {u00D7}10⁻³ M PmCl with slope of 58mV/decade. The detection and quantification limits were 8 {u00D7} 10⁻⁶ and 1x10⁻⁵ M PmCl, respectively. The pH of the tested solution within the range of 4.2 - 6.8 did not affect the electrode performance with high selectivity toward (Pm⁺) cations. The standard addition and potentiometric titration methods were applied for the determination of the drug in its pharmaceutical preparations with a recovery from 97.3 to 100.2% and relative standard deviation (RSD) of 0.35 - 1.83%. In voltammetry, the usable concentration ranges of the calibration graphs for cyclic voltammetric and chronoamperometric determinations were found to be 5x10⁻⁵-1x10⁻² and 5x10⁻⁵ to 5x10⁻³ M PmCl using phosphate buffer solution at pH 5.0 and anodic peak potential of 680 mV. The standard addition and calibration curve methods were applied for the determination of PmCl in its pharmaceutical preparations with a recovery of 93.8-105.7% and RSD of 0.13-0.85 %. The detection and quantification limits were found to be (2.5x10⁻⁷ and 5x10⁻⁵) and (3x10⁻⁵ and 5x10⁻⁵ M) PmCl for cyclic voltammetry and chronoamperometry, respectively.