الفهرس 
Some potential genetic markers for prediction of treatment response in HCV affected Egyptian children
LIST OF CONTENTSOnly 14 pages are availabe for public view
 |  | from | 190 |  |  |
| | | from | 190 | | |
Abstract
Egypt has a high prevalence of hepatitis C virus (HCV) infection in children. Limitations of the current HCV treatment are low rate of sustained virological response (SVR) approximately 50%, significant side effects and high expenses, making prediction of treatment response crucial. This study aimed to investigate association of single nucleotide polymorphisms (SNPs) in IL10, IL28B and IL29 genes in predicting treatment response in HCV infected children. Seventy three Egyptian pediatric patients, receiving pegylated interferon Ü 2b (PEG-IFN Ü 2b) and ribavirin were included, for whom liver biopsy was performed for evaluation of fibrosis score. Genotyping of SNPs in IL10 gene (rs1800896, rs302109, and rs1800872), IL28B gene (rs12979860, rs8099917) and IL29 gene (rs30461) as well as HCV genotype were analyzed by Real - time PCR. The CC genotype (IL28B; rs12979860) had 6.62 folds higher chance to develop SVR than CT and TT genotypes (p = 0.004). The G allele (SNP rs8099917; IL28B), was 2.257 times more likely to be resistant to HCV therapy than the protective T allele (P = 0.04). The CC/TT IL28B haplotype had 6.632 times more chance to respond to HCV therapy compared to other haplotypes P = 0.008