الفهرس 
The role of BCL2 and BAK genes in chronic kidney disease and haemodialysis patients
AbstractOnly 14 pages are availabe for public view
 |  | from | 131 |  |  |
| | | from | 131 | | |
Abstract
Polymorphonuclear leucocytes are the first line of defence against foreign invaders and constitute the major cell type involved in certain types of acute and chronic inflammatory diseases. The aim of the present study was to investigate the changes in gene expressions of members of BCL2 family; BCL2 and BAK genes by real time PCR and to study whether they were involved in the accelerated neutrophil apoptosis which might be responsible for the recurrent bacterial infections seen in chronic renal disease and hemodialysis patients and to clarify their potential therapeutic benefit. This study was conducted on sixty two subjects. Patients were selected from those admitted to the Nephrology Department and Hemodialysis Unit, Theodor Bilharz Research Institute (TBRI). Patients under study were classified into three groups; CKD patients (group I) kept on conservative treatment with no previous history of dialysis (22cases), ESRD patients (group II) maintained on dialysis therapy, HD (20cases). In addition, twenty healthy individuals served as a control group (group III) were involved