الفهرس 
Renal Histopathological Changes and Clinical characteristics of Nephropathy Associated with Antiphospholipid Antibodies in Systemic Lupus Erythematosus Patients.
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Abstract
The aim of the study is to evaluate the renal histopathological changes and clinical characteristics of nephropathy associated with antiphospholipid antibodies in systemic lupus erythematosus patients, compared to nephropathy in the absence of antiphospholipid antibodies. Results: the existence of APSN was strongly associated with aPLs positivity (P=0.016). The prevalence of APSN was 34% among lupus nephritis patients; it was detected in 52% and 16% in aPLs positive and aPLs negative patients respectively. APSN was significantly associated with older age (P=0.032). No statistical significant difference between patients with APSN and those without APSN in terms of renal functions, proteiuria, urine analysis findings, systemic hypertension and APS manifestations (P>0.05 for all). However, acute APSN (thrombotic microangiopathy; TMA), but not chronic APSN, was strongly associated with renal dysfunction and systemic hypertension (P<0.05 for all). Overall APSN, acute APSN (TMA) and chronic APSN were strongly Abstract associated with LAC positivity and titer (P<0.05 for all), but neither aCLs IgG nad IgM nor anti-Ý2GPI IgG and IgM. The detection of APSN was significantly associated with higher chronicity index score, more interstitial fibrosis and tubular atrophy (P<0.05 for all)