الفهرس 
Vascular Endothelial Growth Factor (VEGF), Interleukin 1- alpha (IL-1?) and Tumor Necrosis Factor-alpha (TNF- ?) and Their Relationship with the Dental Pulp in Blood Disordered Patients
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Abstract
Haemoglobinopathy is usually restricted to the inherited disorders of the synthesis of globin chain giving rise to thalassaemia or defect in the structure of the globin chain that produces the classic 2sickle shape3 of the red blood cell leading to sickle cell anaemia. The study aimed to detect VEGF, IL- 1- Ü and TNF- Ü from normal and irreversibly inflamed pulps from both medically healthy (group A and B) and blood disordered patients (group C and D) by immunohistochemical method. The results revealed that group A was least statistically significant difference as compared to the other three groups when testing VEGF, IL- 1- Ü and TNF- Ü. Pearson{u2019}s correlation, group B showed moderate negative correlation between VEGF and IL1- Ü, in group C, strong negative correlation was between VEGF and TNF- Ü, while in group D, strong positive correlation was between VEGF and TNF- Ü. The optimal cut-off points of VEGF, TNF- Ü and IL1- Ü were 4.37%, 1.75% and 2.82%, respectively. The sensitivity was (86.21%, 96.55% and 93.1%), respectively, while the specificity of VEGF, TNF- Ü and IL1- Ü was 80%, 80%, and 90%, respectively