الفهرس 
C0Bhemotherapy induced ovarian failure after adjuvant treatment for early breast cancer: National Cancer Institute experience
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Abstract
Introduction: Breast cancer is the most common cancer and the highest cause of cancer mortality in women worldwide. It is increasingly reported in young premenopausal women in Egypt. Adjuvant chemotherapy improves survival; however, it has a unique consequence of ovarian failure in premenopausal patients. Objective: This study{u2019}s aim was to find the incidence of chemotherapy- induced ovarian failure and reversible amenorrhea in premenopausal non- metastatic breast cancer patients. Method: This study follows premenopausal breast cancer patients receiving chemotherapy refered to Medical Oncology Clinic in National Cancer Institute. It included all patients with early breast cancer with at least a minimum follow up of one year after last cycle of adjuvant chemotherapy and patients were asked about their menstrual history. Results: The study included 100 Egyptian female patients. The mean age of the subjects was 45 years. Of the patients, 56 were amenorrheic at completion of study and 44 regained menstruations, on average after 8 (range 2{u2013}24) months post-chemotherapy. Age was the only statistically significant risk factor.