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Abstract
HCV is a major cause of chronic hepatitis and HCC. Different HCV genotypes show characteristic variations in their pathological properties. IR occurs early in HCV infection and may synergize with viral hepatitis in HCC development. Egypt has the highest reported rates of HCV infection (predominantly genotype 4) in the world; this study investigated effects of HCV- 4 on prevalence of insulin resistance in CHC and HCC in Egyptian patients. 50 CHC patients, 50 HCC patients and 20 normal subjects were studied. IR was estimated using HOMA-IR index and HCV-4 load was determined using real-time polymerase chain reaction. Hepatitis B virus was excluded by ELISA. Standard laboratory and histopathological investigations were undertaken to characterize liver function and for grading and staging of CHC; HCC staging was undertaken using intraoperative samples