الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
 |  | from | 249 |  |  |
| | | from | 249 | | |
المستخلص
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies to components of the cell nucleus. The term antiphospholipid syndrome (APS) refers to a characteristic antibody - mediated thrombophilia; thrombotic events and pregnancy morbidity. The diagnosis of APS should be made on the presence of the characteristic clinical manifestations in association with persistently positive anticardiolipin / aCL IgM or IgG, anti - ß2glycoprotein I / anti - Ý2GPI IgM or IgG or lupus anticoagulant (LA). Antiphospholipid antibodies of immnnolglobulin A isotype were excluded from APS classification criteria based on lacking specificity and providing no additional information. Moreover, they are not fully standardized. Furthermore, there is a considerable difference among the studied ethnicities. Most of the studies supporting the usefulness of IgA aPL are of different designs. In addition their benefit could not be verified because they are commonly found in association with other antibodies