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Abstract
Background: The thalassemia syndromes represent the most common causes of ineffective erythropoiesis . The increased but ineffective erythropoiesis resulting in tissue iron overload induces numerous endocrine diseases, hepatic cirrhosis, cardiac failure and even death . Objectives: we aim to study GDF15 levels in Ý- thalassemia intermedia patients and to correlate its level to their iron status and different clinical and laboratory disease parameters. Method: This is case control study conducted on 25 pediatric patients under 18 years with beta thalassemia intermedia and 30 healthy children taken as control group . GDF 15 level was performed using ( ELISA) kit in serum samples that obtained from children of both groups . Abdominal examination , frequency of blood transfusion , Complete blood picture , Reticulocytic count , liver function tests , serum ferritin were done in case group to assess severity of beta thalassemia intermedia