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Abstract The optimal route to delivery cardioplegia solution in patients with ischemic heart disease undergoing CABG surgery is still debatable. The objective of this study is to find out the optimum route to deliver cardioplegia in patients with left main coronary artery stenotic disease (whether left main stem or left main equivalent) undergoing CABG surgery. A randomized controlled study on 100 patients with left main stem or left main equivalent coronary artery disease undergoing CABG. Patients were divided into two groups; (group A, used antegrade cardioplegia n = 50) and (group AR, used combined antegrade / retrograde cardioplegia n = 50) both groups were administered the same type of cardioplegia. Cardiac troponin T and CKMB activity were measured in all patients 24 and 48 hours respectively after surgery. Aortic cross - clamp time, total bypass time, recovery rhythm and the need for defibrillation shocks whether in the O.R or I.C.U were all recorded. In addition to ECG monitoring and use of inotropic support intraoperative and in the ICU |