الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Myoglobinuric acute renal failure is the most important life threatening complication of rhabdomyolysis. Iron, free radicals, nitric oxide and Cytochrome P450 are involved in the pathogenesis of mARF. The aim of this study was comparing the effect of cimetidine, L-carnitine and both agents on mARF in rats. Forty rats were divided into 5 groups; group 1: control rats. The remaining rats were injected with 50% glycerol (10 ml/kg, i.m.) and were divided into: group 2: myoglobinuric ARF, group3: received L-carnitine (200 mg/kg, i.p.), group 4: received cimetidine (150 mg/kg i.p) and group 5: received both agents together. Forty eight hours later, systolic blood pressure (SBP) was measured. Urine and blood samples were collected to evaluate urine volume, GFR, BUN, creatinine, K, Na, serum creatine kinase, NO and glutathione levels. Kidney specimens were taken to investigate renal cytochrome P450 and for histopathological examination