الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
The aim of this thesis was to improve the bioavailability, provide targeting to the receptor site and bypasses the blood brain barrier so as to achieve the desired drug concentration at the site of action. The factors affecting particle size, and entrapment efficiency percentage of rivastigmine liposomes were studied. The results showed thin film hydration followed by water bath sonication with three consecutive freeze and thaw cycles was the optimum preparation technique of RVT liposomes giving a PS of 349.8 ± 4.67 nm and EE% of 41.6 ± 0.99%. Three attempts were carried to increase the stability of the formed liposomes by preparing rigid liposomes, electrosteric liposomes, and electrosteric stealth liposomes. L- II - S: DDAB molar ratio of 1:0.02, and L - II - S: Tween 80 molar ratio of 1:0.25 (F - OP) were chosen with a desirability of 0.75. Electrosteric stealth liposomes (F - ESS) were prepared from this optimized formula by pegylation of the optimized liposomes with 2 mol% PEG - DSPE